AIE-featured tetraphenylethylene nanoarchitectures in biomedical application: Bioimaging, drug delivery and disease treatment

The development of aggregation-induced emission (AIE) has received extreme considerations from basic and clinical researches. To date, various luminogens with AIE property (AIEgens) have been broadly utilized in optoelectronic devices, fluorescent bio-probes, drug delivery, anticancer chemosensors many more. Scientists likewise dedicated to investigating the possibilities AIEgens biomedical field. Among luminophores studied, tetraphenylethylene (TPE) derivatives demonstrated as most promising AIEgen, owing their capacity self-organization conjugation aggregation-caused quenching (ACQ) fluorophores form larger multi-component assemblies. It generally different fields, like organic therapeutic science, supramolecular chemistry, electronics, cancer therapy, apoptosis inflammation, microorganism imaging therapy etc. This review encompasses recent advances TPE based AIE-active potential applications biomolecular science.